|Application ||WB, IHC-P, FC, IF, E|
|Other Accession||Q5BJU5, O35089, Q401C0, NP_872359.1|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||18931 Da|
|Antigen Region||31-59 aa|
|Other Names||Protein cornichon homolog 2, CNIH-2, Cornichon family AMPA receptor auxiliary protein 2, Cornichon-like protein, CNIH2, CNIL|
|Target/Specificity||This CNIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-59 amino acids from the N-terminal region of human CNIH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNIH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).|
|Tissue Location||Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the transport and maturation of proteins (By similarity).
Hoshino, H., et al. Mol. Biol. Cell 18(4):1143-1152(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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