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Fagilis (IFITM3) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Fagilis (IFITM3) Antibody (Center) AP1153c
    Western blot analysis of IFITM3 (arrow) using rabbit polyclonal IFITM3 Antibody (C-term) (Cat# AP1153c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IFITM3 gene (Lane 2) (Origene Technologies).
  • WB - Fagilis (IFITM3) Antibody (Center) AP1153c
    Western blot analysis of anti-IFITM3 Antibody (Center) (Cat# AP1153c) in Hela cell line lysates (35ug/lane). IFITM3(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01628
Other Accession Q9CQW9, Q99J93, Q01629, P13164
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 14632 Da
Antigen Region 64-93 aa
Additional Information
Gene ID 10410
Other Names Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U, IFITM3
Target/Specificity This Fagilis (IFITM3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the Central region of human Fagilis (IFITM3).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFagilis (IFITM3) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
Cellular Location Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein
Research Areas
Citations ( 0 )


The family of interferon-induced transmembrane protein (Ifitm/mil/fragilis) cell surface proteins may modulate cell adhesion and influence cell differentiation.


Tanaka,S.S., Dev. Cell 9 (6), 745-756 (2005)

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$ 295.00
$ 99.00
Cat# AP1153c
(40 western blots)
Availability: In Stock
Bulk Size
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