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MAML1 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP11558c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP11558c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MAML1 Antibody (Center) - Product info | |
| Application | WB, FC
|
| Primary Accession | Q92585 |
| Other Accession | NP_055572.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 108054 Da |
MAML1 Antibody (Center) - Additional info | |
| Gene ID 9794 | |
| Other Names MAML1; KIAA0200; Mastermind-like protein 1 | |
| Target/Specificity This MAML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human MAML1. | |
| Dilution WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions MAML1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
MAML1 Antibody (Center) - Protein Information | |
| Name MAML1 | |
| Synonyms KIAA0200 | |
| Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions | |
| Cellular Location Nucleus speckle. Note=Nuclear, in a punctate manner | |
| Tissue Location Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen | |
MAML1 Antibody (Center) - Related products
MAML1 Antibody (Center) - Application data
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MAML1 Antibody (Center) (Cat. #AP11558c) western blot analysis in 293,NCI-H460 cell line lysates (35ug/lane).This demonstrates the MAML1 antibody detected the MAML1 protein (arrow).
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MAML1 Antibody (Center) (Cat. #AP11558c) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
MAML1 Antibody (Center) - Research Areas
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BACKGROUND
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Lindberg, M.J., et al. FASEB J. 24(7):2396-2404(2010) Hao, L., et al. Oncogene 29(2):201-213(2010) Saint Just Ribeiro, M., et al. Curr. Protein Pept. Sci. 10(6):570-576(2009) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
