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MAML1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q92585 |
| Other Accession | NP_055572.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 108054 Da |
| Antigen Region | 198-225 aa |
| Gene ID | 9794 |
|---|---|
| Other Names | Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632) |
| Target/Specificity | This MAML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-225 amino acids from the Central region of human MAML1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAML1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAML1 (HGNC:13632) |
|---|---|
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. |
| Cellular Location | Nucleus speckle. Note=Nuclear, in a punctate manner |
| Tissue Location | Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lindberg, M.J., et al. FASEB J. 24(7):2396-2404(2010)
Hao, L., et al. Oncogene 29(2):201-213(2010)
Saint Just Ribeiro, M., et al. Curr. Protein Pept. Sci. 10(6):570-576(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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