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MAML1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAML1 Antibody (Center) AP11558C
    MAML1 Antibody (Center) (Cat. #AP11558c) western blot analysis in 293,NCI-H460 cell line lysates (35ug/lane).This demonstrates the MAML1 antibody detected the MAML1 protein (arrow).
  • FC - MAML1 Antibody (Center) AP11558C
    MAML1 Antibody (Center) (Cat. #AP11558c) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92585
Other Accession NP_055572.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108054 Da
Antigen Region 198-225 aa
Additional Information
Gene ID 9794
Other Names Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632)
Target/Specificity This MAML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-225 amino acids from the Central region of human MAML1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAML1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAML1 (HGNC:13632)
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Cellular Location Nucleus speckle. Note=Nuclear, in a punctate manner
Tissue Location Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen
Research Areas
Citations (0)

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This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lindberg, M.J., et al. FASEB J. 24(7):2396-2404(2010)
Hao, L., et al. Oncogene 29(2):201-213(2010)
Saint Just Ribeiro, M., et al. Curr. Protein Pept. Sci. 10(6):570-576(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 295.00
$ 99.00
Cat# AP11558C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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