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GUCY2D Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • FC - GUCY2D Antibody (Center) AP11569c
    Overlay histogram showing Hela cells stained with AP11569c (green line). The cells were fixed with 2% paraformaldehyde (10 min). The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AP11569c, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(OH191631) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • WB - GUCY2D Antibody (Center) AP11569c
    Anti-GUCY2D Antibody (Center) at 1:2000 dilution + rat eyeball lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 120 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - GUCY2D Antibody (Center) AP11569c
    GUCY2D Antibody (Center) (Cat. #AP11569c) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the GUCY2D antibody detected the GUCY2D protein (arrow).
  • IHC-P - GUCY2D Antibody (Center) AP11569c
    GUCY2D Antibody (Center) (Cat. #AP11569c)immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GUCY2D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02846
Other Accession NP_000171.1
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 120059 Da
Antigen Region 540-570 aa
Additional Information
Gene ID 3000
Other Names Retinal guanylyl cyclase 1, RETGC-1, Guanylate cyclase 2D, retinal, Rod outer segment membrane guanylate cyclase, ROS-GC, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Target/Specificity This GUCY2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D.
Dilution FC~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGUCY2D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells
Research Areas
Citations (0)

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This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].


Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51(5):2608-2614(2010)
Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) :

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$ 295.00
$ 99.00
Cat# AP11569c
(40 western blots)
Availability: In Stock
Bulk Size
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