|Application ||WB, FC, E|
|Calculated MW||44854 Da|
|Antigen Region||268-296 aa|
|Other Names||Serpin B4, Leupin, Peptidase inhibitor 11, PI-11, Squamous cell carcinoma antigen 2, SCCA-2, SERPINB4, PI11, SCCA2|
|Target/Specificity||This SPB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human SPB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPB4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a protease inhibitor to modulate the host immune response against tumor cells.|
|Cellular Location||Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level|
|Tissue Location||Squamous cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SPB4 may act as a protease inhibitor to modulate the host immune response against tumor cells.
Murakami, A., et al. Int. J. Oncol. 36(6):1395-1400(2010)
Higgins, W.J., et al. J. Biol. Chem. 285(6):3722-3729(2010)
Villano, G., et al. Int. J. Mol. Med. 25(1):137-143(2010)
Ahmed, S.T., et al. Biochem. Biophys. Res. Commun. 378(4):821-825(2009)
Yamane, Y., et al. Int. Arch. Allergy Immunol. 150(1):89-101(2009)
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