|Application ||WB, FC, E|
|Calculated MW||44854 Da|
|Antigen Region||268-296 aa|
|Other Names||Serpin B4, Leupin, Peptidase inhibitor 11, PI-11, Squamous cell carcinoma antigen 2, SCCA-2, SERPINB4, PI11, SCCA2|
|Target/Specificity||This SPB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human SPB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPB4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a protease inhibitor to modulate the host immune response against tumor cells.|
|Cellular Location||Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level|
|Tissue Location||Squamous cells.|
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Provided below are standard protocols that you may find useful for product applications.
SPB4 may act as a protease inhibitor to modulate the host immune response against tumor cells.
Murakami, A., et al. Int. J. Oncol. 36(6):1395-1400(2010)
Higgins, W.J., et al. J. Biol. Chem. 285(6):3722-3729(2010)
Villano, G., et al. Int. J. Mol. Med. 25(1):137-143(2010)
Ahmed, S.T., et al. Biochem. Biophys. Res. Commun. 378(4):821-825(2009)
Yamane, Y., et al. Int. Arch. Allergy Immunol. 150(1):89-101(2009)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.