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RUTBC1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RUTBC1 Antibody (C-term) AP11573b
    RUTBC1 Antibody (C-term) (Cat. #AP11573b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the RUTBC1 antibody detected the RUTBC1 protein (arrow).
  • IHC-P - RUTBC1 Antibody (C-term) AP11573b
    RUTBC1 Antibody (C-term) (Cat. #AP11573b)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RUTBC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O43147
Other Accession NP_001091979.1, NP_055668.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 113285 Da
Antigen Region 955-984 aa
Additional Information
Gene ID 9905
Other Names Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1, SGSM2, KIAA0397, RUTBC1
Target/Specificity This RUTBC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 955-984 amino acids from the C-terminal region of human RUTBC1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRUTBC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGSM2
Synonyms KIAA0397, RUTBC1
Function Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).
Cellular Location Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

The specific function of the protein remains unknown.

References

Vasan, R.S., et al. JAMA 302(2):168-178(2009)
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Yang, H., et al. Genomics 90(2):249-260(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 295.00
$ 99.00
Cat# AP11573b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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