|Application ||WB, IHC-P, E|
|Other Accession||NP_001091979.1, NP_055668.2|
|Calculated MW||113285 Da|
|Antigen Region||955-984 aa|
|Other Names||Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1, SGSM2, KIAA0397, RUTBC1|
|Target/Specificity||This RUTBC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 955-984 amino acids from the C-terminal region of human RUTBC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RUTBC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).|
|Cellular Location||Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A.|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The specific function of the protein remains unknown.
Vasan, R.S., et al. JAMA 302(2):168-178(2009)
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Yang, H., et al. Genomics 90(2):249-260(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)
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