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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SFRP4 Antibody (C-term)   

SFRP4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SFRP4 Antibody (C-term) AP11574b
    SFRP4 Antibody (C-term) (Cat. #AP11574b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SFRP4 antibody detected the SFRP4 protein (arrow).
  • FC - SFRP4 Antibody (C-term) AP11574b
    SFRP4 Antibody (C-term) (Cat. #AP11574b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6FHJ7
Other Accession NP_003005.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39827 Da
Antigen Region 318-346 aa
Additional Information
Gene ID 6424
Other Names Secreted frizzled-related protein 4, sFRP-4, Frizzled protein, human endometrium, FrpHE, SFRP4, FRPHE
Target/Specificity This SFRP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the C-terminal region of human SFRP4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSFRP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFRP4
Synonyms FRPHE
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
Cellular Location Secreted. Note=Cytoplasmic in ovarian tumor cells
Tissue Location Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level)
Research Areas
Citations (0)

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Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.


Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)
Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)
Frank, B., et al. Carcinogenesis 31(8):1381-1386(2010)
Huang, D., et al. J. Cancer Res. Clin. Oncol. 136(3):395-401(2010)
Hirata, H., et al. Cancer 115(19):4488-4503(2009)

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$ 295.00
$ 99.00
Cat# AP11574b
(40 western blots)
Availability: In Stock
Bulk Size
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