- CITATIONS: 1
|Application ||WB, FC, E|
|Other Accession||Q5E9S3, NP_003197.2, NP_938206.1|
|Calculated MW||19715 Da|
|Antigen Region||144-173 aa|
|Other Names||Transcription factor 21, TCF-21, Capsulin, Class A basic helix-loop-helix protein 23, bHLHa23, Epicardin, Podocyte-expressed 1, Pod-1, TCF21, BHLHA23, POD1|
|Target/Specificity||This TCF21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human TCF21.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCF21 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.|
Provided below are standard protocols that you may find useful for product applications.
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Smith, L.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(4):982-987(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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