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HCFC1R1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HCFC1R1 Antibody (N-term) AP11644A
    HCFC1R1 Antibody (N-term) (Cat. #AP11644a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the HCFC1R1 antibody detected the HCFC1R1 protein (arrow).
  • IHC-P - HCFC1R1 Antibody (N-term) AP11644A
    HCFC1R1 Antibody (N-term) (Cat. #AP11644a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HCFC1R1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NWW0
Other Accession NP_001002018.1, NP_001002017.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 1-30 aa
Additional Information
Other Names Host cell factor C1 regulator 1, HCF-1 beta-propeller-interacting protein, HCFC1R1, HPIP
Target/Specificity This HCFC1R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HCFC1R1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHCFC1R1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCFC1R1
Synonyms HPIP
Function Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner
Tissue Location Widely expressed. EMBL; AY116892; AAM49798.1; -; mRNA EMBL; AK000575; BAA91265.1; -; mRNA EMBL; CR457245; CAG33526.1; -; mRNA EMBL; CH471112; EAW85425.1; -; Genomic_DNA EMBL; CH471112; EAW85426.1; -; Genomic_DNA EMBL; BC064026; AAH64026.1; -; mRNA EMBL; BC080178; AAH80178.1; -; mRNA CCDS; CCDS10490.1; -. [Q9NWW0-1] CCDS; CCDS32375.1; -. [Q9NWW0-2] RefSeq; NP_001002017.1; NM_001002017.2. [Q9NWW0-2] RefSeq; NP_001002018.1; NM_001002018.2. [Q9NWW0-1] RefSeq; NP_001275594.1; NM_001288665.1. [Q9NWW0-1] RefSeq; NP_001275595.1; NM_001288666.1. [Q9NWW0-2] RefSeq; NP_001275596.1; NM_001288667.1 RefSeq; NP_001275597.1; NM_001288668.1 RefSeq; NP_060355.1; NM_017885.3. [Q9NWW0-1] UniGene; Hs.423103; - ProteinModelPortal; Q9NWW0; - BioGrid; 120320; 3 IntAct; Q9NWW0; 1 MINT; MINT-1424323; - iPTMnet; Q9NWW0; - PhosphoSitePlus; Q9NWW0; - BioMuta; HCFC1R1; - PaxDb; Q9NWW0; - PRIDE; Q9NWW0; - DNASU; 54985; - Ensembl; ENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1] Ensembl; ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2] Ensembl; ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1] GeneID; 54985; - KEGG; hsa:54985; - UCSC; uc002csy.3; human. [Q9NWW0-1] CTD; 54985; - GeneCards; HCFC1R1; - HGNC; HGNC:21198; HCFC1R1 HPA; HPA059647; - neXtProt; NX_Q9NWW0; - OpenTargets; ENSG00000103145; - PharmGKB; PA134951485; - eggNOG; ENOG410IZTH; Eukaryota eggNOG; ENOG4111EF3; LUCA GeneTree; ENSGT00390000015785; - HOGENOM; HOG000112942; - HOVERGEN; HBG107981; - InParanoid; Q9NWW0; - OrthoDB; EOG091G0VZ8; - PhylomeDB; Q9NWW0; - TreeFam; TF338381; - BioCyc; ZFISH:ENSG00000103145-MONOMER; - ChiTaRS; HCFC1R1; human GenomeRNAi; 54985; - PRO; PR:Q9NWW0; - Proteomes; UP000005640; Chromosome 16 Bgee; ENSG00000103145; - CleanEx; HS_HCFC1R1; - ExpressionAtlas; Q9NWW0; baseline and differential Genevisible; Q9NWW0; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell InterPro; IPR029195; HCFC1R1 Pfam; PF15226; HPIP; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome CHAIN 1 138 Host cell factor C1 regulator 1 /FTId=PRO_0000338978 REGION 76 79 Interaction with HCFC1 MOTIF 110 119 Nuclear export signal VAR_SEQ 32 51 SSPLRGAVPMSTKRRLEEEQ -> R (in isoform 2) /FTId=VSP_034082 VARIANT 92 92 P -> Q (in dbSNP:rs10508) /FTId=VAR_043849 MUTAGEN 76 79 DHPY->AAPA: Loss of interaction with HCFC1. MUTAGEN 117 119 LRL->ARA: Reduces nuclear export SEQUENCE 138 AA; 15291 MW; 34A9A04735276A16 CRC64; MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG DTPSPPYPAT PAGDIMEL
Research Areas
Citations (0)

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Background

Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Mahajan, S.S., et al. J. Biol. Chem. 277(46):44292-44299(2002)

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$ 295.00
$ 99.00
Cat# AP11644A
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(40 western blots)
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