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PLAG1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PLAG1 Antibody (N-term) AP11647a
    All lanes : Anti-PLAG1 Antibody (N-term) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - PLAG1 Antibody (N-term) AP11647a
    PLAG1 Antibody (N-term) (Cat. #AP11647a) western blot analysis in NCI-H460,K562 cell line lysates (35ug/lane).This demonstrates the PLAG1 antibody detected the PLAG1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6DJT9
Other Accession Q58NQ5, NP_001108106.1, NP_002646.2
Reactivity Human
Predicted Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55909 Da
Antigen Region 8-35 aa
Additional Information
Gene ID 5324
Other Names Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein, PLAG1
Target/Specificity This PLAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of human PLAG1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLAG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLAG1
Function Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Cellular Location Nucleus Note=Strong nucleolar localization when sumoylation is inhibited
Tissue Location Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors
Research Areas
Citations (0)

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Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.


Patz, M., et al. Leuk. Lymphoma 51(8):1379-1381(2010)
Declercq, J., et al. Diabetes 59(8):1957-1965(2010)
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

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$ 295.00
$ 99.00
Cat# AP11647a
(40 western blots)
Availability: In Stock
Bulk Size
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