|Application ||WB, E|
|Other Accession||Q8VEJ3, NP_055235.1|
|Calculated MW||24876 Da|
|Antigen Region||162-189 aa|
|Other Names||Dickkopf-related protein 4, Dickkopf-4, Dkk-4, hDkk-4, Dickkopf-related protein 4 short form, DKK4|
|Target/Specificity||This DKK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-189 amino acids from the C-terminal region of human DKK4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DKK4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).|
|Tissue Location||Expressed in cerebellum, T-cells, esophagus and lung|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Hirata, H., et al. Cancer 115(19):4488-4503(2009)
Matsui, A., et al. Cancer Sci. 100(10):1923-1930(2009)
Baehs, S., et al. Cancer Lett. 276(2):152-159(2009)
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