|Application ||WB, E|
|Calculated MW||96659 Da|
|Antigen Region||599-629 aa|
|Other Names||Poly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal|
|Target/Specificity||This Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-629 amino acidsof mouse Parp9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Parp9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity).|
|Tissue Location||Highly expressed in the thymus and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.
Hakme, A., et al. Dev. Dyn. 237(1):209-215(2008)
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