|Application ||WB, E|
|Calculated MW||96659 Da|
|Antigen Region||599-629 aa|
|Other Names||Poly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal|
|Target/Specificity||This Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-629 amino acidsof mouse Parp9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Parp9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity).|
|Tissue Location||Highly expressed in the thymus and intestine.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.
Hakme, A., et al. Dev. Dyn. 237(1):209-215(2008)
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