|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||19746 Da|
|Antigen Region||17-45 aa|
|Other Names||Probetacellulin, Betacellulin, BTC, BTC|
|Target/Specificity||This BTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human BTC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.|
|Cellular Location||Betacellulin: Secreted, extracellular space.|
|Tissue Location||Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor.
Stoeck, A., et al. J. Cell. Sci. 123 (PT 13), 2319-2331 (2010) :
Genetos, D.C., et al. Cell Tissue Res. 340(1):81-89(2010)
Nagaoka, T., et al. J. Mol. Biol. 380(1):83-94(2008)
Revillion, F., et al. Ann. Oncol. 19(1):73-80(2008)
Moss, M.L., et al. J. Biol. Chem. 282(49):35712-35721(2007)
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