|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||19746 Da|
|Antigen Region||17-45 aa|
|Other Names||Probetacellulin, Betacellulin, BTC, BTC|
|Target/Specificity||This BTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human BTC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.|
|Cellular Location||Betacellulin: Secreted, extracellular space.|
|Tissue Location||Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor.
Stoeck, A., et al. J. Cell. Sci. 123 (PT 13), 2319-2331 (2010) :
Genetos, D.C., et al. Cell Tissue Res. 340(1):81-89(2010)
Nagaoka, T., et al. J. Mol. Biol. 380(1):83-94(2008)
Revillion, F., et al. Ann. Oncol. 19(1):73-80(2008)
Moss, M.L., et al. J. Biol. Chem. 282(49):35712-35721(2007)
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