|Application ||WB, IHC-P, FC, E|
|Calculated MW||62736 Da|
|Antigen Region||496-528 aa|
|Other Names||Glypican-6, Secreted glypican-6, GPC6|
|Target/Specificity||This GPC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-528 amino acids from the C-terminal region of human GPC6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPC6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side|
|Tissue Location||Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lau, C.S., et al. Br J Ophthalmol 94(3):357-362(2010)
Calboli, F.C., et al. PLoS ONE 5 (7), E11504 (2010) :
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Campos-Xavier, A.B., et al. Am. J. Hum. Genet. 84(6):760-770(2009)
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