|Application ||WB, E|
|Other Accession||Q9CQQ8, NP_057283.1|
|Calculated MW||11602 Da|
|Antigen Region||45-72 aa|
|Other Names||U6 snRNA-associated Sm-like protein LSm7, LSM7|
|Target/Specificity||This LSM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the C-terminal region of human LSM7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LSM7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.|
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Provided below are standard protocols that you may find useful for product applications.
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Ingelfinger, D., et al. RNA 8(12):1489-1501(2002)
Conte, N., et al. Oncogene 21(36):5619-5630(2002)
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