|Application ||WB, FC, E|
|Other Accession||NP_002206.2, NP_001159908.1, NP_001159906.1|
|Calculated MW||101389 Da|
|Antigen Region||606-635 aa|
|Other Names||Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Inter-alpha-inhibitor heavy chain 1, Inter-alpha-trypsin inhibitor complex component III, Serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1|
|Target/Specificity||This ITIH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-635 amino acids from the Central region of human ITIH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITIH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
So, H.C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 103-113 (2010) :
Scott, L.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7501-7506(2009)
Hamm, A., et al. BMC Cancer 8, 25 (2008) :
Scarchilli, L., et al. J. Biol. Chem. 282(41):30161-30170(2007)
Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
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