|Application ||WB, FC, E|
|Other Accession||NP_002591.2, NP_001032418.1|
|Calculated MW||83343 Da|
|Antigen Region||189-217 aa|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, DPDE4, PDE32, PDE4B, DPDE4|
|Target/Specificity||This PDE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-217 amino acids from the Central region of human PDE4B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.|
|Tissue Location||Expressed in brain, heart, lung and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Souza, R.P., et al. Int Clin Psychopharmacol 25(5):264-269(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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