|Application ||WB, E|
|Other Accession||Q76IC5, Q9ESW8, NP_060182.1|
|Calculated MW||23138 Da|
|Antigen Region||22-51 aa|
|Other Names||Pyroglutamyl-peptidase 1, 5-oxoprolyl-peptidase, Pyroglutamyl aminopeptidase I, PAP-I, Pyroglutamyl-peptidase I, PGP-I, Pyrrolidone-carboxylate peptidase, PGPEP1, PGPI|
|Target/Specificity||This PGPEP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human PGPEP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PGPEP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Removes 5-oxoproline from various penultimate amino acid residues except L-proline.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Pyroglutamyl peptidase I (EC 220.127.116.11) catalyzes the hydrolysis of N-terminal pyroglutamyl residues from oligopeptides and proteins.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Valdivia, A., et al. Regul. Pept. 122(2):79-84(2004)
Minderman, H., et al. Clin. Cancer Res. 10(5):1826-1834(2004)
Dando, P.M., et al. Protein Expr. Purif. 28(1):111-119(2003)
Gil, J., et al. Neuropeptides 35 (5-6), 276-284 (2001) :
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