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QTRTD1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IF, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H974 |
| Other Accession | NP_078914.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46713 Da |
| Antigen Region | 321-350 aa |
| Gene ID | 79691 |
|---|---|
| Other Names | Queuine tRNA-ribosyltransferase subunit QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043}, 24229 {ECO:0000255|HAMAP-Rule:MF_03043}, Queuine tRNA-ribosyltransferase domain-containing protein 1 {ECO:0000255|HAMAP-Rule:MF_03043}, QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043} |
| Target/Specificity | This QTRTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-350 amino acids from the C-terminal region of human QTRTD1. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | QTRTD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | QTRT2 {ECO:0000255|HAMAP-Rule:MF_03043} |
|---|---|
| Synonyms | QTRTD1 |
| Function | Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP- Rule:MF_03043} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).
References
Chen, Y.C., et al. RNA 16(5):958-968(2010) Lamesch, P., et al. Genomics 89(3):307-315(2007)
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