|Application ||WB, IHC-P, IF, E|
|Other Accession||Q99PF5, Q3U0V1, NP_003676.2|
|Calculated MW||73115 Da|
|Antigen Region||470-498 aa|
|Other Names||Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2|
|Target/Specificity||This KHSRP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the Central region of human KHSRP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KHSRP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs.|
|Cellular Location||Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.|
|Tissue Location||Detected in neural and non-neural cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).
Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010)
Bikkavilli, R.K., et al. J. Cell. Sci. 123 (PT 8), 1352-1362 (2010) :
Malz, M., et al. Hepatology 50(4):1130-1139(2009)
Trabucchi, M., et al. Nature 459(7249):1010-1014(2009)
Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :
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