|Application ||WB, IHC-P, FC, E|
|Other Accession||Q2KIC8, NP_001093110.1, NP_060756.2|
|Calculated MW||14386 Da|
|Antigen Region||93-122 aa|
|Other Names||Transmembrane protein 100, TMEM100|
|Target/Specificity||This TMEM100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 amino acids from the C-terminal region of human TMEM100.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMEM100 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER) Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system|
|Tissue Location||Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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