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BRUNOL6 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BRUNOL6 Antibody (N-term) AP11714a
    BRUNOL6 Antibody (N-term) (Cat. #AP11714a) western blot analysis in mouse kidney,liver tissue lysates (35ug/lane).This demonstrates the BRUNOL6 antibody detected the BRUNOL6 protein (arrow).
    detail
  • IHC-P - BRUNOL6 Antibody (N-term) AP11714a
    BRUNOL6 Antibody (N-term) (Cat. #AP11714a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BRUNOL6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96J87
Other Accession Q7TN33, NP_001166155.1, NP_443072.3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50477 Da
Antigen Region 46-74 aa
Additional Information
Gene ID 60677
Other Names CUGBP Elav-like family member 6, CELF-6, Bruno-like protein 6, CUG-BP- and ETR-3-like factor 6, RNA-binding protein BRUNOL-6, CELF6, BRUNOL6
Target/Specificity This BRUNOL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human BRUNOL6.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBRUNOL6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CELF6
Synonyms BRUNOL6
Function RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney.
Research Areas
Citations (0)
citation

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Background

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

References

Ladd, A.N., et al. J. Biol. Chem. 279(17):17756-17764(2004)
Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :
Good, P.J., et al. J. Biol. Chem. 275(37):28583-28592(2000)

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$ 365.00
$ 140.00
Cat# AP11714a
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