|Application ||WB, IHC-P, E|
|Other Accession||Q7TMX5, Q3MHH1, NP_060600.2|
|Calculated MW||65125 Da|
|Antigen Region||58-86 aa|
|Other Names||Protein SHQ1 homolog, SHQ1|
|Target/Specificity||This SHQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human SHQ1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SHQ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.|
|Cellular Location||Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies Absent from most H/ACA-box RNA transcription sites|
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Grozdanov, P.N., et al. RNA 15(6):1188-1197(2009)
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