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SOX1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SOX1 Antibody (N-term) AP11764a
    SOX1 Antibody (N-term) (Cat. #AP11764a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SOX1 antibody detected the SOX1 protein (arrow).
  • FC - SOX1 Antibody (N-term) AP11764a
    SOX1 Antibody (N-term) (Cat. #AP11764a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession O00570
Other Accession Q9DDD7, P47792, Q6EJB7, P48433, Q5FWM3, P55863, O42569, P48432, P48431, Q6P0E1, P48430, Q2PG84, P53783, O57401, Q2Z1R2, Q6DGL6, B0ZTE2, Q04892, P61259, O95416, Q32PP9, Q9W7R6, NP_005977.2, P54231
Reactivity Human
Predicted Xenopus, Zebrafish, Chicken, Mouse, Sheep
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 47-76 aa
Additional Information
Other Names Transcription factor SOX-1, SOX1
Target/Specificity This SOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the N-terminal region of human SOX1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX1
Function Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Tissue Location Mainly expressed in the developing central nervous system EMBL; Y13436; CAA73847.1; -; Genomic_DNA EMBL; AL138691; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471085; EAX09158.1; -; Genomic_DNA CCDS; CCDS9523.1; - RefSeq; NP_005977.2; NM_005986.2 UniGene; Hs.202526; - ProteinModelPortal; O00570; - SMR; O00570; - BioGrid; 112539; 2 IntAct; O00570; 1 STRING; 9606.ENSP00000330218; - iPTMnet; O00570; - PhosphoSitePlus; O00570; - BioMuta; SOX1; - MaxQB; O00570; - PaxDb; O00570; - PeptideAtlas; O00570; - PRIDE; O00570; - ProteomicsDB; 47981; - Ensembl; ENST00000330949; ENSP00000330218; ENSG00000182968 GeneID; 6656; - KEGG; hsa:6656; - UCSC; uc001vsb.2; human CTD; 6656; - DisGeNET; 6656; - EuPathDB; HostDB:ENSG00000182968.4; - GeneCards; SOX1; - HGNC; HGNC:11189; SOX1 MIM; 602148; gene neXtProt; NX_O00570; - OpenTargets; ENSG00000182968; - PharmGKB; PA36026; - eggNOG; ENOG410IPZ0; Eukaryota eggNOG; ENOG41102MY; LUCA GeneTree; ENSGT00760000118988; - HOGENOM; HOG000231647; - HOVERGEN; HBG105663; - InParanoid; O00570; - KO; K09267; - OMA; HSRGPCP; - OrthoDB; EOG091G0F15; - PhylomeDB; O00570; - TreeFam; TF351735; - GenomeRNAi; 6656; - PRO; PR:O00570; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000182968; - CleanEx; HS_SOX1; - Genevisible; O00570; HS GO; GO:0005634; C:nucleus; NAS:UniProtKB GO; GO:0003677; F:DNA binding; NAS:UniProtKB GO; GO:0003700; F:DNA binding transcription factor activity; NAS:UniProtKB GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:UniProtKB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl GO; GO:0006325; P:chromatin organization; NAS:UniProtKB GO; GO:0021884; P:forebrain neuron development; IEA:Ensembl GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl GO; GO:0001764; P:neuron migration; IEA:Ensembl GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf InterPro; IPR031268; SOX-1 InterPro; IPR022097; SOX_fam PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1 Pfam; PF00505; HMG_box; 1 Pfam; PF12336; SOXp; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 1: Evidence at protein level; Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 391 Transcription factor SOX-1 /FTId=PRO_0000048712 DNA_BIND 51 119 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} COMPBIAS 27 43 Poly-Gly COMPBIAS 145 150 Poly-Gly COMPBIAS 197 204 Poly-Ala COMPBIAS 280 288 Poly-Ala COMPBIAS 296 306 Poly-Ala COMPBIAS 357 364 Poly-Ala CONFLICT 165 165 A -> P (in Ref. 1; CAA73847) CONFLICT 180 180 G -> A (in Ref. 1; CAA73847) CONFLICT 226 227 AH -> RT (in Ref. 1; CAA73847) CONFLICT 287 290 Missing (in Ref. 1; CAA73847) SEQUENCE 391 AA; 39023 MW; DD519BA97CF5E052 CRC64; MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
Research Areas
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Background

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.

References

Panayi, H., et al. J. Neurosci. 30(37):12274-12280(2010)
Phi, J.H., et al. J Neurosurg Pediatr 5(6):608-614(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Titulaer, M.J., et al. J. Clin. Oncol. 27(26):4260-4267(2009)
Stolk, L., et al. Nat. Genet. 41(6):645-647(2009)

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$ 295.00
$ 99.00
Cat# AP11764a
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(40 western blots)
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