|Application ||WB, FC, E|
|Other Accession||Q9DDD7, P47792, Q6EJB7, P48433, Q5FWM3, P55863, O42569, P48432, P48431, Q6P0E1, P48430, Q2PG84, P53783, O57401, Q2Z1R2, Q6DGL6, B0ZTE2, Q04892, P61259, O95416, Q32PP9, Q9W7R6, NP_005977.2, P54231|
|Predicted||Chicken, Zebrafish, Monkey, Mouse, Xenopus|
|Calculated MW||39023 Da|
|Antigen Region||47-76 aa|
|Other Names||Transcription factor SOX-1, SOX1|
|Target/Specificity||This SOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the N-terminal region of human SOX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOX1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
|Tissue Location||Mainly expressed in the developing central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.
Panayi, H., et al. J. Neurosci. 30(37):12274-12280(2010)
Phi, J.H., et al. J Neurosurg Pediatr 5(6):608-614(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Titulaer, M.J., et al. J. Clin. Oncol. 27(26):4260-4267(2009)
Stolk, L., et al. Nat. Genet. 41(6):645-647(2009)
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