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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RHEB Antibody (C-term)   

RHEB Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RHEB Antibody (C-term) AP11767b
    RHEB Antibody (C-term) (Cat. #AP11767b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the RHEB antibody detected the RHEB protein (arrow).
  • IHC-P - RHEB Antibody (C-term) AP11767b
    RHEB Antibody (C-term) (Cat. #AP11767b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RHEB Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15382
Other Accession Q62639, Q921J2, Q56JV3, NP_005605.1
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20497 Da
Antigen Region 104-134 aa
Additional Information
Gene ID 6009
Other Names GTP-binding protein Rheb, Ras homolog enriched in brain, RHEB, RHEB2
Target/Specificity This RHEB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-134 amino acids from the C-terminal region of human RHEB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRHEB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RHEB2
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Cellular Location Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Research Areas
Citations (0)

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This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.


Zheng, H., et al. Cancer Lett. 297(1):117-125(2010)
Kim, H.W., et al. Mol. Cell. Biol. 30(22):5406-5420(2010)
Karassek, S., et al. J. Biol. Chem. 285(44):33979-33991(2010)
Wagner, R.J., et al. Am. J. Physiol., Cell Physiol. 299 (1), C119-C127 (2010) :
Lu, Z.H., et al. Cancer Res. 70(8):3287-3298(2010)

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$ 295.00
$ 99.00
Cat# AP11767b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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