|Application ||WB, IHC-P, E|
|Other Accession||P07091, P35466, NP_062427.1, NP_002952.1|
|Calculated MW||11729 Da|
|Antigen Region||1-30 aa|
|Other Names||Protein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100A4, CAPL, MTS1|
|Target/Specificity||This S100A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human S100A4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S100A4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Ma, X., et al. Cancer Lett. 299(2):171-181(2010)
Miranda, K.J., et al. J. Biol. Chem. 285(41):31517-31524(2010)
van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)
Cunningham, M.F., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (2), G457-G466 (2010) :
Mencia, N., et al. BMC Cancer 10, 250 (2010) :
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