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AGBL5 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP11785a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP11785a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
AGBL5 Antibody (N-term) - Product info | |
| Application | WB, IHC, IF
|
| Primary Accession | Q8NDL9 |
| Other Accession | Q58CX9, NP_068603.4 |
| Reactivity | Human |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 97534 Da |
AGBL5 Antibody (N-term) - Additional info | |
| Gene ID 60509 | |
| Other Names AGBL5; CCP5; Cytosolic carboxypeptidase-like protein 5; ATP/GTP-binding protein-like 5 | |
| Target/Specificity This AGBL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human AGBL5. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AGBL5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AGBL5 Antibody (N-term) - Protein Information | |
| Name AGBL5 | |
| Synonyms CCP5 | |
| Function Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 (By similarity) | |
| Cellular Location Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity) | |
| Tissue Location Expressed in brain. | |
AGBL5 Antibody (N-term) - Related products
AGBL5 Antibody (N-term) - Application data
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AGBL5 Antibody (N-term) (Cat. #AP11785a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the AGBL5 antibody detected the AGBL5 protein (arrow).
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AGBL5 Antibody (N-term) (Cat. #AP11785a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AGBL5 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Confocal immunofluorescent analysis of AGBL5 Antibody (N-term)(Cat#AP11785a) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
AGBL5 Antibody (N-term) - Research Areas
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BACKGROUND
AGBL5 has a function in the processing of cytosolic proteins such as alpha tubulin, which is known to be modified by the removal of a C terminal tyrosine. It is expressed in the brain. There are three named isoforms.
REFERENCES
Bailey, S.D., et al. Diabetes Care (2010) In press : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006) Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
