|Application ||WB, IHC-P, E|
|Calculated MW||106374 Da|
|Antigen Region||398-425 aa|
|Other Names||Nuclear pore complex protein Nup107, 107 kDa nucleoporin, Nucleoporin Nup107, NUP107|
|Target/Specificity||This NUP107 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-425 amino acids from the Central region of human NUP107.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUP107 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.|
|Cellular Location||Nucleus membrane Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755)|
|Tissue Location||Ubiquitously expressed in fetal and adult tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Kim, S.Y., et al. Biochem. Biophys. Res. Commun. 401(1):131-136(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Mishra, R.K., et al. Nat. Cell Biol. 12(2):164-169(2010)
Platani, M., et al. Mol. Biol. Cell 20(24):5260-5275(2009)
Whittle, J.R., et al. J. Biol. Chem. 284(41):28442-28452(2009)
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