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SLCO4C1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SLCO4C1 Antibody (C-term) AP11795B
    SLCO4C1 Antibody (C-term) (Cat. #AP11795b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SLCO4C1 antibody detected the SLCO4C1 protein (arrow).
  • IHC-P - SLCO4C1 Antibody (C-term) AP11795B
    SLCO4C1 Antibody (C-term) (Cat. #AP11795b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLCO4C1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - SLCO4C1 Antibody (C-term) AP11795B
    SLCO4C1 Antibody (C-term) (Cat. #AP911795b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZQN7
Other Accession NP_851322.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 78948 Da
Antigen Region 516-544 aa
Additional Information
Gene ID 353189
Other Names Solute carrier organic anion transporter family member 4C1, OATP-H, Organic anion transporter M1, OATP-M1, Solute carrier family 21 member 20, SO4C1
Target/Specificity This SLCO4C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-544 amino acids from the C-terminal region of human SLCO4C1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLCO4C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SO4C1
Function Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion- transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
Cellular Location Basolateral cell membrane {ECO:0000250|UniProtKB:Q71MB6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney {ECO:0000250|UniProtKB:Q71MB6}
Tissue Location Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney
Research Areas
Citations (0)

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SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yamaguchi, H., et al. Drug Metab. Pharmacokinet. 25(3):314-317(2010)
Toyohara, T., et al. J. Am. Soc. Nephrol. 20(12):2546-2555(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Tripodi, G., et al. Am. J. Hypertens. 22(4):357-363(2009)

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Cat# AP11795B
(40 western blots)
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