|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_001035817.1, NP_001035853.1, NP_001035849.1|
|Calculated MW||48423 Da|
|Antigen Region||178-207 aa|
|Other Names||Tyrosine-protein phosphatase non-receptor type 20, hPTPN20, PTPN20A|
|Target/Specificity||This PTPN20A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-207 amino acids from the Central region of human PTPN20A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPN20A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments|
|Tissue Location||Present in many cell lines (at protein level). Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Fodero-Tavoletti, M.T., et al. Biochem. J. 389 (PT 2), 343-354 (2005) :
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