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> home > Products > Primary Antibodies > Antibody Collections > Ubiquitin E3 Ligases (RING Domain) Antibodies > TRIM56 Antibody (C-term)
TRIM56 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BRZ2 |
| Other Accession | NP_112223.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 81488 Da |
| Antigen Region | 727-755 aa |
| Gene ID | 81844 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM56, 632-, RING finger protein 109, Tripartite motif-containing protein 56, TRIM56, RNF109 |
| Target/Specificity | This TRIM56 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 727-755 amino acids from the C-terminal region of human TRIM56. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM56 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM56 {ECO:0000303|PubMed:21289118, ECO:0000312|HGNC:HGNC:19028} |
|---|---|
| Function | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host- derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
TRIM56 belongs to the TRIM/RBCC family. It contains 2 B box-type zinc fingers and a RING-type zinc finger. There are 3 named isoforms produced by alternative splicing.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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$ 182.50
$ 70.00
Cat# AP11813b
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