|Application ||WB, FC, E|
|Other Accession||NP_443210.1, NP_055978.4|
|Calculated MW||79177 Da|
|Antigen Region||648-676 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM9, 632-, RING finger protein 91, Tripartite motif-containing protein 9, TRIM9, KIAA0282, RNF91|
|Target/Specificity||This TRIM9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 648-676 amino acids from the C-terminal region of human TRIM9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.|
|Cellular Location||Cytoplasm. Cell projection, dendrite Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity) Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum|
|Tissue Location||Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.
Tanji, K., et al. Neurobiol. Dis. 38(2):210-218(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Li, Y., et al. J. Biol. Chem. 276(44):40824-40833(2001)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
Ohara, O., et al. DNA Res. 4(1):53-59(1997)
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