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PDE1B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP11846B 400 µl
(40 western blots)
In Stock $ 265.00 Add to cart
AP11846B-ev 80 µl
(8 western blots)
In Stock $ 95.00 Add to cart
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PDE1B Antibody (C-term) - Product Information

Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • ICC=Immunocytochemistry
  • CHIP=Chromatin Immunoprecipitation
  • E=ELISA
  • IHCF=Immunohistochemistry (Frozen Sections)
  • FA=Fluorescence Assay
  • IHCP=Immunohistochemistry (Paraffin-embedded Sections)
  • IC=Immunochemistry
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary AccessionQ01064
Other AccessionNP_000915.1, NP_001159447.1
ReactivityMouse
HostRabbit
ClonalityPolyclonal
Isotype Rabbit Ig
Calculated MW 61380 Da
Antigen Region 473-500 aa

PDE1B Antibody (C-term) - Additional Information

Gene ID 5153
Other Names
Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B
Target/Specificity
This PDE1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of human PDE1B.
Dilution
WB~~1:1000
IHC~~1:10~50
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
PDE1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

PDE1B Antibody (C-term) - Protein Information

Name PDE1B
Synonyms PDE1B1, PDES1B
Function
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Cellular Location
Cytoplasm.

PDE1B Antibody (C-term) - Related Products

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AT3252a: PDE1B Antibody (monoclonal) (M02)

AO1827a: PDE1B Antibody

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AO1833a: PDE1B Antibody

AO1834a: PDE1B Antibody

PDE1B Antibody (C-term) - Research Areas

Application Data

  • WB - PDE1B Antibody (C-term) AP11846B

    PDE1B Antibody (C-term) (Cat. #AP11846b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PDE1B antibody detected the PDE1B protein (arrow).

  • IHC - PDE1B Antibody (C-term) AP11846B

    PDE1B Antibody (C-term) (Cat. #AP11846b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE1B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

  • WB - PDE1B Antibody (C-term) AP11846B
  • IHC - PDE1B Antibody (C-term) AP11846B

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Vandeput, F., et al. J. Biol. Chem. 282(45):32749-32757(2007)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(2):460-465(2006)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 102(2):497-502(2005)