|Application ||IHC-P, WB, IF, E|
|Calculated MW||24051 Da|
|Antigen Region||203-230 aa|
|Other Names||GSK-3-binding protein FRAT2, Frequently rearranged in advanced T-cell lymphomas 2, FRAT-2, FRAT2|
|Target/Specificity||This FRAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-230 amino acids from the C-terminal region of human FRAT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRAT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)
Liu, G.P., et al. Neurobiol. Aging 29(9):1348-1358(2008)
Stoothoff, W.H., et al. J. Biol. Chem. 280(1):270-276(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Freemantle, S.J., et al. Gene 291 (1-2), 17-27 (2002) :
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