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MYLK3 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MYLK3 Antibody (Center) AP11849c
    MYLK3 Antibody (Center) (Cat. #AP11849c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MYLK3 antibody detected the MYLK3 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q32MK0
Other Accession NP_872299.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 88393 Da
Antigen Region 535-562 aa
Additional Information
Gene ID 91807
Other Names Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, MYLK3, MLCK
Target/Specificity This MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-562 amino acids from the Central region of human MYLK3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYLK3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYLK3
Synonyms MLCK
Function Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).
Cellular Location Cytoplasm.
Tissue Location Restricted to heart..
Research Areas
Citations (0)
citation

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Background

Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).

References

Al-Sadi, R., et al. J. Immunol. 180(8):5653-5661(2008)
Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)
Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)

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$ 365.00
$ 140.00
Cat# AP11849c
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