|Application ||WB, E|
|Calculated MW||88393 Da|
|Antigen Region||535-562 aa|
|Other Names||Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, MYLK3, MLCK|
|Target/Specificity||This MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-562 amino acids from the Central region of human MYLK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYLK3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).|
|Tissue Location||Restricted to heart.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).
Al-Sadi, R., et al. J. Immunol. 180(8):5653-5661(2008)
Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)
Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)
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