|Application ||WB, IHC-P, E|
|Other Accession||Q6AY23, Q922Q4, Q4R6W7, Q17QJ7, NP_037460.2|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||33637 Da|
|Antigen Region||89-116 aa|
|Other Names||Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2, PYCR2|
|Target/Specificity||This PYCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-116 amino acids from the Central region of human PYCR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PYCR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).|
|Cellular Location||Cytoplasm. Mitochondrion|
|Tissue Location||Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).|
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Provided below are standard protocols that you may find useful for product applications.
PYCR2 belongs to the pyrroline-5-carboxylate reductase family. Pyrroline-5-carboxylate reductase catalyzes the the NAD(P)H-dependent conversion of proline to pyrroline-5-carboxylate.
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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