|Application ||WB, IHC-P, E|
|Other Accession||Q6AY23, Q922Q4, Q4R6W7, Q17QJ7, NP_037460.2|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||33637 Da|
|Antigen Region||89-116 aa|
|Other Names||Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2, PYCR2|
|Target/Specificity||This PYCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-116 amino acids from the Central region of human PYCR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PYCR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).|
|Cellular Location||Cytoplasm. Mitochondrion|
|Tissue Location||Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PYCR2 belongs to the pyrroline-5-carboxylate reductase family. Pyrroline-5-carboxylate reductase catalyzes the the NAD(P)H-dependent conversion of proline to pyrroline-5-carboxylate.
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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