|Application ||IHC-P, WB, E|
|Other Accession||A5A4K9, Q95254, NP_940799|
|Calculated MW||41329 Da|
|Antigen Region||326-357 aa|
|Other Names||Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, GHRP, Ghrelin receptor, GHSR|
|Target/Specificity||This GHSR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-357 amino acids from the C-terminal region of human GHSR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GHSR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary and hypothalamus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Landgren, S., et al. Alcohol. Clin. Exp. Res. 34(9):1519-1524(2010)
Aghajanova, L., et al. Reprod Sci 17(9):823-832(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
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