|Application ||WB, FC, E|
|Other Accession||Q9JJK1, NP_005269|
|Calculated MW||28989 Da|
|Antigen Region||1-30 aa|
|Other Names||Neuronal membrane glycoprotein M6-b, M6b, GPM6B, M6B|
|Target/Specificity||This GPM6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPM6B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPM6B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalizes with SERT at the plasma membrane.|
|Tissue Location||Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions, such as membrane trafficking and cell-to-cell communication.
Fjorback, A.W., et al. J. Mol. Neurosci. 37(3):191-200(2009)
Sebastiani, P., et al. Am. J. Hematol. 83(3):189-195(2008)
Combes, P., et al. Neurogenetics 7(1):31-37(2006)
Henneke, M., et al. Am. J. Med. Genet. A 128A (2), 156-158 (2004) :
Werner, H., et al. Mol. Cell. Neurosci. 18(6):593-605(2001)
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