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GPM6B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GPM6B Antibody (N-term) AP11878a
    GPM6B Antibody (N-term) (Cat. #AP11878a) western blot analysis in ZR-75-1,CEM cell line lysates (35ug/lane).This demonstrates the GPM6B antibody detected the GPM6B protein (arrow).
    detail
  • FC - GPM6B Antibody (N-term) AP11878a
    GPM6B Antibody (N-term) (Cat. #AP11878a) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q13491
Other Accession Q9JJK1, NP_005269
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28989 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 2824
Other Names Neuronal membrane glycoprotein M6-b, M6b, GPM6B, M6B
Target/Specificity This GPM6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPM6B.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPM6B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPM6B
Synonyms M6B
Function May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Colocalizes with SERT at the plasma membrane.
Tissue Location Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia
Research Areas
Citations (0)
citation

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Background

This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions, such as membrane trafficking and cell-to-cell communication.

References

Fjorback, A.W., et al. J. Mol. Neurosci. 37(3):191-200(2009)
Sebastiani, P., et al. Am. J. Hematol. 83(3):189-195(2008)
Combes, P., et al. Neurogenetics 7(1):31-37(2006)
Henneke, M., et al. Am. J. Med. Genet. A 128A (2), 156-158 (2004) :
Werner, H., et al. Mol. Cell. Neurosci. 18(6):593-605(2001)

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$ 365.00
$ 140.00
Cat# AP11878a
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