SHISA6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q6ZSJ9 |
Other Accession | Q3UH99, NP_997269.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55764 Da |
Antigen Region | 81-109 aa |
Gene ID | 388336 |
---|---|
Other Names | Protein shisa-6 homolog, SHISA6 |
Target/Specificity | This SHISA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human SHISA6. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SHISA6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SHISA6 (HGNC:34491) |
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Function | Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. |
Cellular Location | Membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UH99} |
Tissue Location | Expressed in the developing ventral mesencephalon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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