- New Antibodies
- Crown Antibodies
- Stem Cells
- Neurodegeneration >
- GPCR Antibodies
- Gene Ontology >
Biological Process > Cellular Compartment > Molecular Function >
- Pathways >
Biocarta > KEGG > Panther >
- Disease >
- Tissue >
- Tag Antibody
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Biological Process >
- FL cDNA Clones
SET07 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
United StatesOrdering Information
Albania Australia Austria Belgium Bosnia & Herzegovina Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hong Kong Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands New Zealand Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia South Africa Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others
|AP1191b||400 µl (40 western blots)||In Stock||$ 265.00||DISCONTINUED INQUIRE CLICK INQUIRE Add to cart|
|AP1191b-ev||80 µl (8 western blots)||In Stock||$ 95.00||DISCONTINED INQUIRE CLICK INQUIRE Add to cart|
- Citations : 0
SET07 Antibody (C-term) - Product info
|Calculated MW||42890 Da|
SET07 Antibody (C-term) - Additional info
|Gene ID 387893|
SETD8; KMT5A; PRSET7; SET07; SET8; N-lysine methyltransferase SETD8; H4-K20-HMTase SETD8; Histone-lysine N-methyltransferase SETD8; Lysine N-methyltransferase 5A; PR/SET domain-containing protein 07; SET domain-containing protein 8
This SET07 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-393 amino acids from the C-terminal region of human SET07.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
SET07 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
SET07 Antibody (C-term) - Protein Information
|Synonyms KMT5A, PRSET7, SET07, SET8|
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin
SET07 Antibody (C-term) - Related products
SET07 Antibody (C-term) - Research Areas
Western blot analysis of SET07 Antibody (C-term) (Cat. #AP1191b) in K562 cell line lysates (35ug/lane). SET07 (arrow) was detected using the purified Pab.
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Nishioka, K., et al., Mol. Cell 9(6):1201-1213 (2002).
Fang, J., et al., Curr. Biol. 12(13):1086-1099 (2002).