|Application ||WB, E|
|Calculated MW||13075 Da|
|Antigen Region||74-103 aa|
|Other Names||Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, CG-alpha, Follicle-stimulating hormone alpha chain, FSH-alpha, Follitropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Thyrotropin alpha chain, CGA|
|Target/Specificity||This TSH-alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-103 amino acids from the C-terminal region of human TSH-alpha.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSH-alpha Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.|
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Provided below are standard protocols that you may find useful for product applications.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Panicker, V., et al. Am. J. Hum. Genet. 87(3):430-435(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Robinson, N., et al. Clin. Lab. 56 (5-6), 197-206 (2010) :
Bjerner, J., et al. Scand. J. Clin. Lab. Invest. 69(8):873-879(2009)
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