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TSH-alpha Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TSH-alpha Antibody (C-term) AP11925b
    TSH-alpha Antibody (C-term) (Cat. #AP11925b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TSH-alpha antibody detected the TSH-alpha protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P01215
Other Accession NP_000726
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 13075 Da
Antigen Region 74-103 aa
Additional Information
Gene ID 1081
Other Names Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, CG-alpha, Follicle-stimulating hormone alpha chain, FSH-alpha, Follitropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Thyrotropin alpha chain, CGA
Target/Specificity This TSH-alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-103 amino acids from the C-terminal region of human TSH-alpha.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTSH-alpha Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CGA
Function Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Cellular Location Secreted
Research Areas
Citations (0)
citation

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Background

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.

References

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Panicker, V., et al. Am. J. Hum. Genet. 87(3):430-435(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Robinson, N., et al. Clin. Lab. 56 (5-6), 197-206 (2010) :
Bjerner, J., et al. Scand. J. Clin. Lab. Invest. 69(8):873-879(2009)

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$ 365.00
$ 140.00
Cat# AP11925b
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