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ZNF384 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8TF68 |
| Other Accession | NP_597733.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63219 Da |
| Antigen Region | 531-559 aa |
| Gene ID | 171017 |
|---|---|
| Other Names | Zinc finger protein 384, CAG repeat protein 1, CAS-interacting zinc finger protein, Nuclear matrix transcription factor 4, Nuclear matrix protein 4, Trinucleotide repeat-containing gene 1 protein, ZNF384, CAGH1, CIZ, NMP4, TNRC1 |
| Target/Specificity | This ZNF384 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-559 amino acids from the C-terminal region of human ZNF384. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF384 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF384 |
|---|---|
| Synonyms | CAGH1, CIZ, NMP4, TNRC1 |
| Function | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene contains long CAG trinucleotide repeats coding consecutive glutamine residues. The gene product may functions as a transcription factor, with a potential role in the regulation of neurodevelopment or neuroplasticity. The protein appears to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Multiple transcript variants encoding several isoforms have been found for this gene.
References
Alves, J., et al. Biochem. Biophys. Res. Commun. 384(4):495-500(2009)
Zhong, C.H., et al. Leukemia 22(4):723-729(2008)
Janssen, H., et al. Exp. Cell Res. 312(7):1194-1204(2006)
La Starza, R., et al. Leukemia 19(9):1696-1699(2005)
Martini, A., et al. Cancer Res. 62(19):5408-5412(2002)
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