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RAP1GDS1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RAP1GDS1 Antibody (Center) AP11945c
    RAP1GDS1 Antibody (Center) (Cat. #AP11945c) western blot analysis in HepG2,MDA-MB231 cell line lysates (35ug/lane).This demonstrates the RAP1GDS1 antibody detected the RAP1GDS1 protein (arrow).
    detail
  • IHC-P - RAP1GDS1 Antibody (Center) AP11945c
    RAP1GDS1 Antibody (Center) (Cat. #AP11945c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAP1GDS1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P52306
Other Accession NP_001093900.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 66317 Da
Antigen Region 217-244 aa
Additional Information
Gene ID 5910
Other Names Rap1 GTPase-GDP dissociation stimulator 1, Exchange factor smgGDS, SMG GDS protein, SMG P21 stimulatory GDP/GTP exchange protein, RAP1GDS1
Target/Specificity This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the Central region of human RAP1GDS1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAP1GDS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAP1GDS1 {ECO:0000303|Ref.3}
Synonyms SMGGDS {ECO:0000303|Ref.3}
Function Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed:28630045, PubMed:30190425, PubMed:1549351, PubMed:11948427, PubMed:20709748). Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity (PubMed:20709748, PubMed:21242305). Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS (PubMed:1549351, PubMed:11948427, PubMed:20709748, PubMed:24415755). Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions (PubMed:27716788). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085).
Cellular Location Cytoplasm, cytosol. Endoplasmic reticulum. Mitochondrion. Nucleus Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region.
Research Areas
Citations (0)
citation

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Background

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).

References

Schonherr, C., et al. Oncogene 29(19):2817-2830(2010)
Branham, M.T., et al. J. Biol. Chem. 284(37):24825-24839(2009)
Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
Tew, G.W., et al. J. Biol. Chem. 283(2):963-976(2008)
Tiwari, S., et al. Blood 103(7):2661-2667(2004)

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$ 182.50
$ 70.00
Cat# AP11945c
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