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JMJD2B Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - JMJD2B Antibody (N-term) AP11950A
    JMJD2B Antibody (N-term) (Cat. #AP11950a) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the JMJD2B antibody detected the JMJD2B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94953
Other Accession NP_055830
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 121897 Da
Antigen Region 428-459 aa
Additional Information
Gene ID 23030
Other Names Lysine-specific demethylase 4B, 11411-, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, KDM4B, JHDM3B, JMJD2B, KIAA0876
Target/Specificity This JMJD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-459 amino acids from the N-terminal region of human JMJD2B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJMJD2B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4B
Synonyms JHDM3B, JMJD2B, KIAA0876
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959}
Citations (0)

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KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20' and only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.


Yang, J., et al. Cancer Res. 70(16):6456-6466(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Beyer, S., et al. J. Biol. Chem. 283(52):36542-36552(2008)
Pollard, P.J., et al. Biochem. J. 416(3):387-394(2008)
Katoh, Y., et al. Int. J. Mol. Med. 20(2):269-273(2007)

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Cat# AP11950A
(40 western blots)
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