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MGP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P08493 |
| Other Accession | NP_000891.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 12353 Da |
| Antigen Region | 37-66 aa |
| Gene ID | 4256 |
|---|---|
| Other Names | Matrix Gla protein, MGP, Cell growth-inhibiting gene 36 protein, MGP, MGLAP |
| Target/Specificity | This MGP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human MGP. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MGP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MGP |
|---|---|
| Synonyms | MGLAP |
| Function | Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. |
| Cellular Location | Secreted. |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.
References
Romero, R., et al. Am. J. Obstet. Gynecol. (2010) In press :
Bailey, S.D., et al. Diabetes Care (2010) In press :
Parker, B.D., et al. Ann. Intern. Med. 152(10):640-648(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Schurgers, L.J., et al. Clin J Am Soc Nephrol 5(4):568-575(2010)
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