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CD8B1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP11957b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP11957b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
CD8B1 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | P10966 |
| Other Accession | A6NJW9, NP_004922 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 23722 Da |
CD8B1 Antibody (C-term) - Additional info | |
| Gene ID 926 | |
| Other Names CD8B; CD8B1; T-cell surface glycoprotein CD8 beta chain; CD_antigen=CD8b; Flags: Precursor | |
| Target/Specificity This CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human CD8B1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CD8B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CD8B1 Antibody (C-term) - Protein Information | |
| Name CD8B | |
| Synonyms CD8B1 | |
| Function Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing | |
| Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable) Isoform 3: Secreted (Probable). Isoform 5: Cell membrane; Single-pass type I membrane protein (Probable) Isoform 7: Secreted (Probable). | |
| Tissue Location Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells | |
CD8B1 Antibody (C-term) - Related products
AP11957b: CD8B1 Antibody (C-term)
AP1440a: CD8B Antibody (N-term)
DC09167: Human CD8B cDNA Clone
CD8B1 Antibody (C-term) - Application data
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CD8B1 Antibody (C-term) (Cat. #AP11957b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CD8B1 antibody detected the CD8B1 protein (arrow).
CD8B1 Antibody (C-term) - Research Areas
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BACKGROUND
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Chen, M.L., et al. Eur. J. Immunol. 39(12):3423-3435(2009) Thakral, D., et al. J. Immunol. 180(11):7431-7442(2008) Stove, V., et al. J. Virol. 79(17):11422-11433(2005) Moody, A.M., et al. J. Biol. Chem. 278(9):7240-7246(2003)
