|Application ||WB, FC, E|
|Calculated MW||38726 Da|
|Antigen Region||125-154 aa|
|Other Names||Transcription factor AP-4, Activating enhancer-binding protein 4, Class C basic helix-loop-helix protein 41, bHLHc41, TFAP4, BHLHC41|
|Target/Specificity||This TFAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-154 amino acids from the Central region of human TFAP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFAP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'.|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).
Ku, W.C., et al. Mol. Cell Proteomics 8(9):2034-2050(2009)
Cao, J., et al. Int. J. Surg. Pathol. 17(1):16-21(2009)
Jung, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105(39):15046-15051(2008)
Pons, J., et al. Biochemistry 47(1):14-29(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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