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ELMD2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ELMD2 Antibody  (C-term) AP11988b
    ELMD2 Antibody (C-term) (Cat. #AP11988b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ELMD2 antibody detected the ELMD2 protein (arrow).
  • FC - ELMD2 Antibody  (C-term) AP11988b
    ELMD2 Antibody (C-term) (Cat. #AP11988b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q8IZ81
Other Accession NP_714913.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 251-279 aa
Additional Information
Other Names ELMO domain-containing protein 2, ELMOD2
Target/Specificity This ELMD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the C-terminal region of human ELMD2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsELMD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELMOD2
Function Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
Tissue Location Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls EMBL; AK312800; BAG35659.1; -; mRNA EMBL; CH471056; EAX05096.1; -; Genomic_DNA EMBL; CH471056; EAX05097.1; -; Genomic_DNA EMBL; BC015168; AAH15168.2; -; mRNA CCDS; CCDS3752.1; - RefSeq; NP_714913.1; NM_153702.3 RefSeq; XP_005262943.1; XM_005262886.2 RefSeq; XP_011530121.1; XM_011531819.2 UniGene; Hs.450105; - UniGene; Hs.677038; - ProteinModelPortal; Q8IZ81; - BioGrid; 129109; 2 IntAct; Q8IZ81; 2 STRING; 9606.ENSP00000326342; - iPTMnet; Q8IZ81; - PhosphoSitePlus; Q8IZ81; - SwissPalm; Q8IZ81; - BioMuta; ELMOD2; - DMDM; 74728441; - EPD; Q8IZ81; - MaxQB; Q8IZ81; - PaxDb; Q8IZ81; - PeptideAtlas; Q8IZ81; - PRIDE; Q8IZ81; - ProteomicsDB; 71286; - Ensembl; ENST00000323570; ENSP00000326342; ENSG00000179387 GeneID; 255520; - KEGG; hsa:255520; - UCSC; uc003iik.3; human CTD; 255520; - DisGeNET; 255520; - EuPathDB; HostDB:ENSG00000179387.9; - GeneCards; ELMOD2; - HGNC; HGNC:28111; ELMOD2 HPA; HPA047600; - MIM; 610196; gene neXtProt; NX_Q8IZ81; - OpenTargets; ENSG00000179387; - PharmGKB; PA134984145; - eggNOG; KOG2998; Eukaryota eggNOG; ENOG410XRXC; LUCA GeneTree; ENSGT00390000006017; - HOGENOM; HOG000007810; - HOVERGEN; HBG056692; - InParanoid; Q8IZ81; - OMA; KPESIMY; - OrthoDB; EOG091G0E2U; - PhylomeDB; Q8IZ81; - TreeFam; TF323472; - ChiTaRS; ELMOD2; human GenomeRNAi; 255520; - PRO; PR:Q8IZ81; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000179387; - CleanEx; HS_ELMOD2; - ExpressionAtlas; Q8IZ81; baseline and differential Genevisible; Q8IZ81; HS GO; GO:0016020; C:membrane; HDA:UniProtKB GO; GO:0005096; F:GTPase activator activity; IDA:UniProtKB GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW GO; GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB InterPro; IPR006816; ELMO_dom InterPro; IPR030724; ELMOD2 PANTHER; PTHR12771:SF21; PTHR12771:SF21; 1 Pfam; PF04727; ELMO_CED12; 1 PROSITE; PS51335; ELMO; 1 1: Evidence at protein level; Antiviral defense; Complete proteome; GTPase activation; Reference proteome CHAIN 1 293 ELMO domain-containing protein 2 /FTId=PRO_0000225017 DOMAIN 126 282 ELMO. {ECO:0000255|PROSITE- ProRule:PRU00664} SEQUENCE 293 AA; 34961 MW; 339CD216FC46ADD2 CRC64; MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV
Research Areas
Citations (0)

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Background

This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq].

References

Pulkkinen, V., et al. FASEB J. 24(4):1167-1177(2010)
Bowzard, J.B., et al. J. Biol. Chem. 282(24):17568-17580(2007)
Hodgson, U., et al. Am. J. Hum. Genet. 79(1):149-154(2006)

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$ 295.00
$ 99.00
Cat# AP11988b
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(40 western blots)
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