|Application ||WB, FC, E|
|Calculated MW||34961 Da|
|Antigen Region||251-279 aa|
|Other Names||ELMO domain-containing protein 2, ELMOD2|
|Target/Specificity||This ELMD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the C-terminal region of human ELMD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELMD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.|
|Tissue Location||Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq].
Pulkkinen, V., et al. FASEB J. 24(4):1167-1177(2010)
Bowzard, J.B., et al. J. Biol. Chem. 282(24):17568-17580(2007)
Hodgson, U., et al. Am. J. Hum. Genet. 79(1):149-154(2006)
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