|Application ||WB, IHC-P, E|
|Other Accession||Q8WXH6, NP_001027004.1|
|Calculated MW||31239 Da|
|Antigen Region||7-36 aa|
|Other Names||Ras-related protein Rab-40A-like, Ras-like GTPase, RAB40AL, RLGP|
|Target/Specificity||This RAB40AL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human RAB40AL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB40AL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion|
|Tissue Location||Expressed in brain, lung, heart, skeletal muscle, kidney and liver. Highest expression in brain. Expressed in fetal brain and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy.
Saito-Ohara, F., et al. Am. J. Hum. Genet. 71(3):637-645(2002) Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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