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PDE3B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDE3B Antibody (Center) AP12018c
    PDE3B Antibody (Center) (Cat. #AP12018c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PDE3B antibody detected the PDE3B protein (arrow).
  • IF - PDE3B Antibody (Center) AP12018c
    Confocal immunofluorescent analysis of PDE3B Antibody (Center) (Cat#AP12018c) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • FC - PDE3B Antibody (Center) AP12018c
    PDE3B Antibody (Center) (Cat. #AP12018c) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13370
Other Accession NP_000913.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 124333 Da
Antigen Region 400-427 aa
Additional Information
Gene ID 5140
Other Names cGMP-inhibited 3', 5'-cyclic phosphodiesterase B, CGIPDE1, CGIP1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, PDE3B
Target/Specificity This PDE3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-427 amino acids from the Central region of human PDE3B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE3B
Function Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Abundant in adipose tissues.
Research Areas
Citations (0)

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Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes; PDE3B may play a role in fat metabolism.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yamano, Y., et al. Int. J. Cancer 126(2):437-449(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hanson, M.S., et al. Am. J. Physiol. Heart Circ. Physiol. 295 (2), H786-H793 (2008) :
Raymond, D.R., et al. Cell. Signal. 19(12):2507-2518(2007)

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Cat# AP12018c
(40 western blots)
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