|Application ||WB, IF, FC, E|
|Calculated MW||124333 Da|
|Antigen Region||400-427 aa|
|Other Names||cGMP-inhibited 3', 5'-cyclic phosphodiesterase B, CGIPDE1, CGIP1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, PDE3B|
|Target/Specificity||This PDE3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-427 amino acids from the Central region of human PDE3B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundant in adipose tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes; PDE3B may play a role in fat metabolism.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yamano, Y., et al. Int. J. Cancer 126(2):437-449(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hanson, M.S., et al. Am. J. Physiol. Heart Circ. Physiol. 295 (2), H786-H793 (2008) :
Raymond, D.R., et al. Cell. Signal. 19(12):2507-2518(2007)
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